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    6 things you need to know: Genetic markers for glaucoma identified

    Researchers discover five genetic markers for glaucoma

    Researchers recently identified five previously unknown genetic markers that are linked to an increased risk for primary angle closure glaucoma (PACG), according to a study published in Nature.

    The study examined the genetic makeup of more than 40,000 people— 10,503 cases of PACG and 29,567 controls—from 24 countries across Asia, Australia, Europe, North America, and South America.

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    After meta-analysis of all patient collections, researchers identified the following new genetic loci, or specific locations of a gene, as causing an increased risk for PACG:

    EPDR1 rs3816415

    CHAT rs1258267

    GLIS3 rs736893
    FERMT2 rs7494379

    DPM2FAM102A rs3739821

    Researchers say the study also confirmed significant association at three previously described loci:




    “I think genetic testing will come into play in many diseases, including glaucoma,” says Optometry Times Editorial Advisory Board member Ben Casella, OD, FAAO. “As the human genome project continues to teach us—and cost of gene sequencing continues to decrease due to advances in biotechnology and competition among companies— genetic testing will become ever more commonplace in eye care and all of health care.”

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    Colleen E. McCarthy
    Colleen McCarthy is a freelance writer based in the Cleveland area and a former editor of Optometry Times. She is a 2010 graduate of the ...


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