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    Fasting regimens may be key in treating type 2 diabetes

    Keep this in mind for your patients who are interested in disease remission

    Fasting regimens have gained popularity as a technique for reducing weight and obesity.

    This strategy may improve insulin sensitivity in patients with insulin resistance and diabetes.

    A variety of fasting protocols have been proposed, including:

    Intra-day fasting (e.g., no caloric intake 14 to 16 hours each day) or intermittent daily fasting (e.g., no caloric intake for 24 consecutive hours twice per week)

    Partial fasting (also known as the warrior diet, e.g., includes minimal caloric intake for 20 consecutive hours followed by a single, large meal in the evening)

    Alternate daily fasting (e.g., little or no caloric intake every other day followed by “normal” caloric consumption on feeding days—consumption on feeding days typically ranges from 1500 to 2400 calories and on fasting days ranges from 0 to 600 calories)

    These protocols may result in more or less food craving, weight loss, and tolerability for specific people.1

    Previously from Dr. Chous: Importance of adherence and follow-up in patients with diabetic retinopathy

    Fasting works

    The health benefits of caloric restriction in general and fasting regimens in particular have been demonstrated in numerous animal models and observational studies of human populations. There remains uncertainty as to whether the benefits apply to humans over extended periods.

    A randomized controlled clinical trial of obese subjects who are exposed to continuous vs. intermittent calorie restriction is now underway. This study will give us insight into obesity-related metabolic gene expression and inflammatory markers.2

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